Please see Integrated E8, Binary, Octonion for a tutorial that explains the detail of the content of Fano.pdf. It outlines the relationships in the integration of E8 with Octonions, Binary, Particles, NKS, and the Periodic Table of Elements. Other formats are also available (.ppt or .pps and .pdf).
The main change was an improved association of the 120 periodic table elements to the 120 root vectors weighted by their simple root grading. See the full 241 page reference here.